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Infection and Immunity, February 2005, p. 1217-1220, Vol. 73, No. 2
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.2.1217-1220.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Modulation of an Outer Membrane Protease Contributes to the Virulence Defect of Shigella flexneri Strains Carrying a Mutation in the virK Locus

Helen J. Wing ,{dagger},{ddagger} Seth R. Goldman,{dagger} Shabeen Ally, and Marcia B. Goldberg*

Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts

Received 9 July 2004/ Returned for modification 16 September 2004/ Accepted 20 October 2004

The Shigella actin assembly protein IcsA is removed from the bacterial surface by the protease IcsP. We show that decreased intracellular spreading of virK::Tn10 mutants is due in part to significant increases in IcsP and IcsP-mediated cleavage of IcsA and that IcsP expression is a critical determinant of Shigella virulence.

* Corresponding author. Mailing address: Bacterial Pathogenesis Laboratories, University Park, 65 Landsdowne St., Cambridge, MA 02139. Phone: (617) 768-8740. Fax: (617) 768-8738. E-mail: mgoldberg1{at}partners.org.

Editor: J. N. Weiser

{dagger} H.J.W. and S.R.G. contributed equally to this work.

{ddagger} Present address: Department of Biological Sciences, University of Nevada-Las Vegas, Las Vegas.

Infection and Immunity, February 2005, p. 1217-1220, Vol. 73, No. 2
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.2.1217-1220.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Novik, V., Hofreuter, D., Galan, J. E. (2009). Characterization of a Campylobacter jejuni VirK Protein Homolog as a Novel Virulence Determinant. Infect. Immun. 77: 5428-5436 [Abstract] [Full Text]  


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