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Infection and Immunity, March 2005, p. 1873-1878, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1873-1878.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Sublethal Infection of C57BL/6 Mice with Salmonella enterica Serovar Typhimurium Leads to an Increase in Levels of Toll-Like Receptor 1 (TLR1), TLR2, and TLR9 mRNA as Well as a Decrease in Levels of TLR6 mRNA in Infected Organs

Sabine Tötemeyer,1 Pete Kaiser,2 Duncan J. Maskell,1 and Clare E. Bryant1*

Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge,1 Institute for Animal Health, Compton, Newbury, Berkshire, United Kingdom2

Received 25 May 2004/ Returned for modification 23 August 2004/ Accepted 21 October 2004

Sublethal infection of C57BL/6 mice with Salmonella enterica serovar Typhimurium M525P initiates a strong inflammatory response. We measured organ expression of mRNA for Toll-like receptors and their associated signaling molecules during S. enterica serovar Typhimurium infection. During infection, the Toll-lie receptor 1 (TLR1), TLR2, and TLR9 mRNA levels increased, while TLR6 mRNA expression decreased.

* Corresponding author. Mailing address: Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom. Phone: 44-1223-337701. Fax: 44-1223-337610. E-mail: ceb27{at}cam.ac.uk.

Editor: F. C. Fang

Infection and Immunity, March 2005, p. 1873-1878, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1873-1878.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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