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Infection and Immunity, March 2005, p. 1890-1894, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1890-1894.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Both CD1d Antigen Presentation and Interleukin-12 Are Required To Activate Natural Killer T Cells during Trypanosoma cruzi Infection

Malcolm S. Duthie,1 Maria Kahn,1 Maria White,1 Raj P. Kapur,2 and Stuart J. Kahn1*

Infectious Disease Research Institute,1 Department of Pathology, Children's Hospital and Regional Medical Center, Seattle, Washington2

Received 15 September 2004/ Returned for modification 22 October 2004/ Accepted 11 November 2004

Mechanisms of natural killer T (NKT)-cell activation remain unclear. Here, we report that during Trypanosoma cruzi infection, interleukin-12 (IL-12) deficiency or anti-CD1d antibody treatment prevents normal activation. The required IL-12 arises independently of MyD88. The data support a model of normal NKT-cell activation that requires IL-12 and TCR stimulation.

* Corresponding author. Mailing address: IDRI, 1124 Columbia St., Suite 600, Seattle, WA 98104. Phone: (206) 381-0883. Fax: (206) 381-3678. E-mail: skahn{at}idri.org.

Editor: W. A. Petri, Jr.

Infection and Immunity, March 2005, p. 1890-1894, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1890-1894.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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