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Infection and Immunity, May 2005, p. 2910-2922, Vol. 73, No. 5
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.5.2910-2922.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Induction of Mycobacterium tuberculosis-Specific Primary and Secondary T-Cell Responses in Interleukin-15-Deficient Mice

Vanja Lazarevic, David J. Yankura, Sherrie J. Divito, and JoAnne L. Flynn*

Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261

Received 6 December 2004/ Returned for modification 20 December 2004/ Accepted 14 January 2005

Several studies have provided evidence that interleukin-15 (IL-15) can enhance protective immune responses against Mycobacterium tuberculosis infection. However, the effects of IL-15 deficiency on the functionality of M. tuberculosis-specific CD4 and CD8 T cells are unknown. In this study, we investigated the generation and maintenance of effector and memory T-cell responses following M. tuberculosis infection of IL-15–/– mice. IL-15–/– mice had slightly higher bacterial numbers during chronic infection, which were accompanied by an increase in gamma interferon (IFN-{gamma})-producing CD4 and CD8 T cells. There was no evidence of increased apoptosis or a defect in proliferation of CD8 effector T cells following M. tuberculosis infection. The induction of cytotoxic and IFN-{gamma} CD8 T-cell responses was normal in the absence of IL-15 signaling. The infiltration of CD4 and CD8 T cells into the lungs of "immune" IL-15–/– mice was delayed in response to M. tuberculosis challenge. These findings demonstrate that efficient effector CD4 and CD8 T cells can be developed following M. tuberculosis infection in the absence of IL-15 but that recall T-cell responses may be impaired.

* Corresponding author. Mailing address: Department of Molecular Genetics and Biochemistry, W1157 Biomedical Science Tower, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15261. Phone: (412) 624-7743. Fax: (412) 648-3394. E-mail: joanne{at}pitt.edu.

Editor: F. C. Fang

Infection and Immunity, May 2005, p. 2910-2922, Vol. 73, No. 5
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.5.2910-2922.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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