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Infection and Immunity, May 2005, p. 3160-3163, Vol. 73, No. 5
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.5.3160-3163.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Requirement of MgtC for Brucella suis Intramacrophage Growth: a Potential Mechanism Shared by Salmonella enterica and Mycobacterium tuberculosis for Adaptation to a Low-Mg2+ Environment

Jean-Philippe Lavigne, David O'Callaghan, and Anne-Béatrice Blanc-Potard*

Institut National de la Santé et de la Recherche Médicale, Unité 431, UFR de Médecine, CS 83021, Avenue J.F. Kennedy, 30908 NIMES Cedex 02, France

Received 27 September 2004/ Returned for modification 24 November 2004/ Accepted 15 December 2004

A Brucella suis mgtC mutant is defective for growth within macrophages and in low-Mg2+ medium. These phenotypes are strikingly similar to those observed with mgtC mutants from Salmonella enterica and Mycobacterium tuberculosis, two other pathogens that proliferate within phagosomes. MgtC appears as a remarkable virulence factor that would have been acquired by distantly related intracellular pathogens to contribute to the adaptation to a low-Mg2+ environment in the phagosome.

* Corresponding author. Mailing address: Institut National de la Santé et de la Recherche Médicale, Unité 431, UFR de Médecine, CS 83021, Avenue J.F. Kennedy, 30908 NIMES Cedex 02, France. Phone: 33 4 66 02 81 47. Fax: 33 4 66 02 81 48. E-mail: ablancpotard{at}univ-montp1.fr.

Editor: J. B. Bliska

Infection and Immunity, May 2005, p. 3160-3163, Vol. 73, No. 5
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.5.3160-3163.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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