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Infection and Immunity, June 2005, p. 3773-3777, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3773-3777.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Involvement of Sortase Anchoring of Cell Wall Proteins in Biofilm Formation by Streptococcus mutans

Céline M. Lévesque, Elena Voronejskaia, Yi-Chen Cathy Huang, Richard W. Mair, Richard P. Ellen, and Dennis G. Cvitkovitch*

Oral Microbiology, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada

Received 25 October 2004/ Returned for modification 4 January 2005/ Accepted 8 February 2005

Streptococcus mutans is one of the best-known biofilm-forming organisms associated with humans. We investigated the role of the sortase gene (srtA) in monospecies biofilm formation and observed that inactivation of srtA caused a decrease in biofilm formation. Genes encoding three putative sortase-dependent proteins were also found to be up-regulated in biofilms versus planktonic cells and mutations in these genes resulted in reduced biofilm biomass.

* Corresponding author. Mailing address: Oral Microbiology, Faculty of Dentistry, University of Toronto, 124 Edward St., Toronto, Ontario, Canada M5G 1G6. Phone: (416) 979-4917, ext. 4592. Fax: (416) 979-4936. E-mail: dennis.cvitkovitch{at}utoronto.ca.

Editor: V. J. DiRita

Infection and Immunity, June 2005, p. 3773-3777, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3773-3777.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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