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Infection and Immunity, June 2005, p. 3787-3789, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3787-3789.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Recombinant Cysteine Proteinase from Leishmania (Leishmania) chagasi Implicated in Human and Dog T-Cell Responses

Paulo Henrique da Costa Pinheiro,1,2 Suzana de Souza Dias,1 Kelsen Dantas Eulálio,3 Ivete L. Mendonça,4 Simone Katz,1 and Clara Lúcia Barbiéri1*

Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP,1 Division of Parasitology, Faculdade NOVAFAPI, Teresina, PI,2 Division of Infectious and Parasitic Diseases, Universidade Federal do Piauí, Teresina, PI,3 Department of Clinical Veterinary, Universidade Federal do Piauí, Teresina, Piauí, PI, Brazil4

Received 20 October 2004/ Returned for modification 8 December 2004/ Accepted 20 January 2005

High in vitro lymphoproliferative responses were induced in humans and dogs by a recombinant Leishmania (Leishmania) chagasi cysteine proteinase, with secretion of IFN-{gamma} in asymptomatic subjects or of IFN-{gamma}, interleukin 4 (IL-4), and IL-10 in oligosymptomatic subjects. In contrast, responses of symptomatic patients and dogs were lower, with production of IL-4 and IL-10.

* Corresponding author. Mailing address: Division of Parasitology, Universidade Federal de São Paulo, Escola Paulista de Medicina, Rua Botucatu, 862-6o andar, São Paulo, SP, Brazil 04023-062. Phone: 55 11 5576-4532. Fax: 55 11 5571-1095. E-mail: barbiericl{at}ecb.epm.br.

Editor: W. A. Petri, Jr.

Infection and Immunity, June 2005, p. 3787-3789, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3787-3789.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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