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 Previous Article

Infection and Immunity, June 2005, p. 3823-3827, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3823-3827.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

CD4+ T Cells Play a Dominant Role in Protection against New World Leishmaniasis Induced by Vaccination with the P-4 Amastigote Antigen

Sujata Kar,1 Christine Metz,2 and Diane McMahon-Pratt1*

Yale University School of Medicine, Department of Epidemiology and Public Health, 60 College Street, New Haven, Connecticut 06520-8034,1 The Institute for Medical Research at North Shore-LIJ, 350 Community Drive, Manhasset, New York 110302

Received 13 September 2004/ Returned for modification 19 October 2004/ Accepted 16 January 2005

Immunodepletion studies of P-4-vaccinated mice indicate that CD4+ and not CD8+ T cells are critical for protection against Leishmania pifanoi (Leishmania mexicana complex). Although a moderate CD8+ T-cell response is elicited by vaccination, CD4+ T cells are the dominant responding population in vitro and at the cutaneous site of infection. These protective T cells produce gamma interferon (IFN-{gamma}), macrophage migration inhibitory factor (MIF), and tumor necrosis factor/lymphotoxin (TNF/LT), each of which significantly contributed to intracellular parasite destruction in vitro. These results indicate that a singular CD4+ T-cell response (IFN-{gamma}, MIF, and/or LT/TNF) can provide protection against New World cutaneous leishmaniasis.

* Corresponding author. Mailing address: Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, CT 06520-8034. Phone: (203) 785-4481. Fax: (203) 737-2921. E-mail: diane.mcmahon-pratt{at}yale.edu.

Editor: W. A. Petri, Jr.

Infection and Immunity, June 2005, p. 3823-3827, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3823-3827.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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