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Infection and Immunity, August 2005, p. 5238-5240, Vol. 73, No. 8
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.8.5238-5240.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Role for Mannose Binding Lectin in the Prevention of Mycoplasma Infection

Renata M. J. Hamvas,1 Marina Johnson,1 Arine M. Vlieger,3 Clare Ling,4 Andrea Sherriff,5 Angela Wade,2 Nigel J. Klein,1 Malcolm W. Turner,1*,{dagger} The ALSPAC Study Team,4 A. David B. Webster,3,{dagger}

Immunobiology Unit, Institute of Child Health, University College London, United Kingdom,1 Paediatric Epidemiology and Biostatistics Unit, Institute of Child Health, University College, London, United Kingdom,2 Departments of Immunology,3 Medical Microbiology,4 Royal Free Hospital and University College Medical School, London, United Kingdom; and Unit of Paediatric and Perinatal Epidemiology, Institute of Child Health, University of Bristol, Bristol, United Kingdom5

Received 21 July 2004/ Returned for modification 13 October 2004/ Accepted 16 March 2005

Polymorphisms in exon 1 of the MBL-2 gene, resulting in reduced plasma levels of mannose binding lectin, were significantly overrepresented in 23 patients with primary antibody deficiency and culture-proven mycoplasma infections (P = 0.0038). This association persisted with the inclusion of a further nine suspected (doxycycline-responsive) cases (P = 0.0087). The lectin was shown to bind to three strains of mycoplasma.

* Corresponding author. Mailing address: MW Turner, Immunobiology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom. Phone: 44 20 7905 2215. Fax: 44 20 7813 8494. E-mail: mturner{at}ich.ucl.ac.uk.

Editor: J. N. Weiser

{dagger} These authors contributed equally to this study.

Infection and Immunity, August 2005, p. 5238-5240, Vol. 73, No. 8
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.8.5238-5240.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Endeman, H., Herpers, B. L., de Jong, B. A. W., Voorn, G. P., Grutters, J. C., van Velzen-Blad, H., Biesma, D. H. (2008). Mannose-Binding Lectin Genotypes in Susceptibility to Community-Acquired Pneumonia. Chest 134: 1135-1140 [Abstract] [Full Text]  


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