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Infection and Immunity, August 2005, p. 5241-5244, Vol. 73, No. 8
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.8.5241-5244.2005

Staphylococcus aureus Infection of Epidermal Keratinocytes Promotes Expression of Innate Antimicrobial Peptides

Barbara E. Menzies1,2* and Aimee Kenoyer1

Medical Research Service of the Veterans Affairs Puget Sound Health Care System, Seattle, Washington,1 Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington2

Received 21 October 2004/ Returned for modification 26 January 2005/ Accepted 5 April 2005

Keratinocytes upregulate expression of endogenous antimicrobial peptides in response to inflammatory stimuli. We show that both viable and heat-inactivated Staphylococcus aureus and lipoteichoic acid differentially alter expression of these peptides upon contact with human keratinocytes. The findings indicate a diversity of staphylococcal factors involved in upregulation of antimicrobial peptide expression in cutaneous epithelia.

* Corresponding author. Mailing address: Veterans Affairs Puget Sound Health Care System, S-111-ID, 1660 S. Columbian Way, Seattle, WA 98108. Phone: (206) 277-4576. Fax: (206) 764-2689. E-mail: bmenzies{at}u.washington.edu.

Editor: V. J. DiRita

Infection and Immunity, August 2005, p. 5241-5244, Vol. 73, No. 8
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.8.5241-5244.2005




This article has been cited by other articles:

  • Menzies, B. E., Kenoyer, A. (2006). Signal Transduction and Nuclear Responses in Staphylococcus aureus- Induced Expression of Human {beta}-Defensin 3 in Skin Keratinocytes. Infect. Immun. 74: 6847-6854 [Abstract] [Full Text]  
  • Voss, E., Wehkamp, J., Wehkamp, K., Stange, E. F., Schroder, J. M., Harder, J. (2006). NOD2/CARD15 Mediates Induction of the Antimicrobial Peptide Human Beta-defensin-2. J. Biol. Chem. 281: 2005-2011 [Abstract] [Full Text]  


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