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Infection and Immunity, August 2005, p. 5245-5248, Vol. 73, No. 8
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.8.5245-5248.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Recombinant Proteins of Cryptosporidium parvum Induce Proliferation of Mesenteric Lymph Node Cells in Infected Mice

Inderpal Singh,1* Cynthia Theodos,2 and Saul Tzipori1

Division of Infectious Diseases, Department of Biomedical Sciences, Tufts University School of Veterinary Medicine, North Grafton, Massachusetts 01536,1 Biogen Idec Inc., 14 Cambridge Center, Cambridge, Massachusetts 021412

Received 10 February 2005/ Returned for modification 1 March 2005/ Accepted 16 March 2005

Recombinant antigens of Cryptosporidium parvum, Cp900 and Cp40 but not Cp15, stimulated C. parvum-specific proliferative immune responses of mesenteric lymph node cells in C57BL/6J mice infected with different isolates (MD, GCH1, UCP, and IOWA) of C. parvum, indicating that both Cp900 and Cp40 are immunodominant targets of cellular immune responses during C. parvum infection.

* Corresponding author. Mailing address: Division of Infectious Diseases, Department of Biomedical Sciences, Tufts University School of Veterinary Medicine, North Grafton, MA 01536. Phone: (508) 887-4798. Fax: (508) 839-7911. E-mail: inderpal.singh{at}tufts.edu.

Editor: T. R. Kozel

Infection and Immunity, August 2005, p. 5245-5248, Vol. 73, No. 8
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.8.5245-5248.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Benitez, A. J., McNair, N., Mead, J. R. (2009). Oral Immunization with Attenuated Salmonella enterica Serovar Typhimurium Encoding Cryptosporidium parvum Cp23 and Cp40 Antigens Induces a Specific Immune Response in Mice. CVI 16: 1272-1278 [Abstract] [Full Text]  


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