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Infection and Immunity, September 2005, p. 6138-6142, Vol. 73, No. 9
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.9.6138-6142.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Complement Receptor 3 Binds the Borrelia burgdorferi Outer Surface Proteins OspA and OspB in an iC3b-Independent Manner

Rodolfo C. Garcia,1* Rossella Murgia,2 and Marina Cinco2

International Centre for Genetic Engineering and Biotechnology, 34012 Trieste,1 Laboratorio Spirochete, Dipartimento di Scienze Biomediche, Universita' di Trieste, 34127 Trieste, Italy2

Received 22 March 2005/ Returned for modification 16 May 2005/ Accepted 17 May 2005

Persistence of borreliae within the vertebrate host depends on the fate of interactions between the spirochetes and target cells. The present work demonstrates the direct binding of the Borrelia burgdorferi outer surface proteins OspA and OspB to CR3 and that this binding is independent of iC3b.

* Corresponding author. Mailing address: Leukocyte Biology Unit, I.C.G.E.B., Area Science Park, 34012 Trieste, Italy. Phone: 39 040 3757371. Fax: 39 040 226555. E-mail: garcia{at}icgeb.org.

Editor: J. T. Barbieri

Infection and Immunity, September 2005, p. 6138-6142, Vol. 73, No. 9
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.9.6138-6142.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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