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Infection and Immunity, January 2006, p. 781-785, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.781-785.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Molecular Characterization of the Escherichia coli Asymptomatic Bacteriuria Strain 83972: the Taming of a Pathogen

Per Klemm,1 Viktoria Roos,1 Glen C. Ulett,2 Catharina Svanborg,3 and Mark A. Schembri2*

Microbial Adhesion Group, Centre for Biomedical Microbiology, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark,1 School of Molecular and Microbial Sciences, University of Queensland, Brisbane QLD 4072, Australia,2 Institute of Laboratory Medicine, Section for Microbiology, Immunology and Glycobiology, Lund University, Sölvegatan 23, SE-223 62 Lund, Sweden3

Received 26 September 2005/ Accepted 5 October 2005

Escherichia coli 83972 is a clinical asymptomatia bacteriuric isolate that is able to colonize the human urinary bladder without inducing an immune response. Here we demonstrate that one of the mechanisms by which this strain has become attenuated is through the mutation of its genes encoding type 1 and P fimbriae.

* Corresponding author. Mailing address: School of Molecular and Microbial Sciences, Building 76, University of Queensland, Brisbane QLD 4072, Australia. Phone: 617 33653306. Fax: 617 33654699. E-mail: m.schembri{at}uq.edu.au.

Editor: V. J. DiRita

Infection and Immunity, January 2006, p. 781-785, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.781-785.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Zdziarski, J., Svanborg, C., Wullt, B., Hacker, J., Dobrindt, U. (2008). Molecular Basis of Commensalism in the Urinary Tract: Low Virulence or Virulence Attenuation?. Infect. Immun. 76: 695-703 [Abstract] [Full Text]  
  • Klemm, P., Hancock, V., Schembri, M. A. (2007). Mellowing Out: Adaptation to Commensalism by Escherichia coli Asymptomatic Bacteriuria Strain 83972. Infect. Immun. 75: 3688-3695 [Full Text]  
  • Hancock, V., Klemm, P. (2007). Global Gene Expression Profiling of Asymptomatic Bacteriuria Escherichia coli during Biofilm Growth in Human Urine. Infect. Immun. 75: 966-976 [Abstract] [Full Text]  
  • Takahashi, A., Kanamaru, S., Kurazono, H., Kunishima, Y., Tsukamoto, T., Ogawa, O., Yamamoto, S. (2006). Escherichia coli Isolates Associated with Uncomplicated and Complicated Cystitis and Asymptomatic Bacteriuria Possess Similar Phylogenies, Virulence Genes, and O-Serogroup Profiles. J. Clin. Microbiol. 44: 4589-4592 [Abstract] [Full Text]  
  • Roos, V., Klemm, P. (2006). Global Gene Expression Profiling of the Asymptomatic Bacteriuria Escherichia coli Strain 83972 in the Human Urinary Tract.. Infect. Immun. 74: 3565-3575 [Abstract] [Full Text]  
  • Roos, V., Schembri, M. A., Ulett, G. C., Klemm, P. (2006). Asymptomatic bacteriuria Escherichia coli strain 83972 carries mutations in the foc locus and is unable to express F1C fimbriae. Microbiology 152: 1799-1806 [Abstract] [Full Text]  


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