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Infection and Immunity, January 2006, p. 790-793, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.790-793.2006

New World Monkey Aotus nancymae as a Model for Campylobacter jejuni Infection and Immunity

Franca R. Jones,1* Shahida Baqar,2 Alfonso Gozalo,1,{dagger} Gladys Nunez,1 Nereyda Espinoza,1 Sharina M. Reyes,2 Milagros Salazar,1 Rina Meza,1 Chad K. Porter,2 and Stephen E. Walz1,{ddagger}

Bacterial Diseases Program, Naval Medical Research Center Detachment (NMRCD—Lima, Peru), NMRCD Unit 3800, APO, AA 34031,1 Enteric Diseases Department, Naval Medical Research Center (NMRC), 503 Robert Grant Avenue, Silver Spring, Maryland 209102

Received 5 October 2005/ Accepted 14 October 2005

Three groups of six monkeys (Aotus nancymae) each were inoculated intragastrically with increasing doses of Campylobacter jejuni. Infection resulted in fecal colonization (100% of monkeys), dose-related diarrhea, and robust immune responses. Colonization duration and diarrhea rate were reduced upon secondary challenge. A. nancymae may be useful for studying anti-Campylobacter vaccine efficacy.

* Corresponding author. Present address: Naval Medical Research Center, Biological Defense Research Directorate, 503 Robert Grant Avenue, Silver Spring, MD 20910. Phone: (301) 319-9937. Fax: (301) 319-7513. E-mail: jonesf{at}nmrc.navy.mil.

Editor: V. J. DiRita

{dagger} Present address: NIAID/CMB, Bldg. 14BS, Room 228, 9000 Rockville Pike, Bethesda, MD 20892.

{ddagger} Present address: Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910.

Infection and Immunity, January 2006, p. 790-793, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.790-793.2006




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