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Infection and Immunity, February 2006, p. 904-909, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.904-909.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Entamoeba histolytica Infection in Children and Protection from Subsequent Amebiasis

Rashidul Haque,1 Dinesh Mondal,1 Priya Duggal,2 Mamun Kabir,1 Shantanu Roy,1 Barry M. Farr,3 R. Bradley Sack,4 and William A. Petri Jr.3*

International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh,1 Inherited Disease Research Branch, National Human Genome Research Institute, NIH, Baltimore, Maryland,2 University of Virginia, Charlottesville, Virginia,3 Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland4

Received 20 September 2005/ Returned for modification 20 October 2005/ Accepted 4 November 2005

The contribution of amebiasis to the burden of diarrheal disease in children and the degree to which immunity is acquired from natural infection were assessed in a 4-year prospective observational study of 289 preschool children in an urban slum in Dhaka, Bangladesh. Entamoeba histolytica infection was detected at least once in 80%, and repeat infection in 53%, of the children who completed 4 years of observation. Annually there were 0.09 episodes/child of E. histolytica-associated diarrhea and 0.03 episodes/child of E. histolytica-associated dysentery. Fecal immunoglobulin A (IgA) anti-parasite Gal/GalNAc lectin carbohydrate recognition domain (anti-CRD) was detected in 91% (183/202) of the children at least once and was associated with a lower incidence of infection and disease. We concluded that amebiasis was a substantial burden on the overall health of the cohort children. Protection from amebiasis was associated with a stool anti-CRD IgA response. The challenge of producing an effective vaccine will be to improve upon naturally acquired immunity, which does not provide absolute protection from reinfection.

* Corresponding author. Mailing address: Division of Infectious Diseases and International Health, University of Virginia Health System, Room 2115, MR4 Building, P.O. Box 801340, Charlottesville, VA 22908-1340. Phone: (434) 924-5621. Fax: (434) 924-0075. E-mail: wap3g{at}virginia.edu.

Editor: J. F. Urban, Jr.

Infection and Immunity, February 2006, p. 904-909, Vol. 74, No. 2
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.2.904-909.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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