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Infection and Immunity, March 2006, p. 1954-1957, Vol. 74, No. 3
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.3.1954-1957.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Modulation of Human Neutrophil Functions In Vitro by Treponema denticola Major Outer Sheath Protein

Bina Puthengady Thomas, Chun Xiang Sun, Elena Bajenova, Richard P. Ellen,{dagger} and Michael Glogauer{dagger}{dagger}

CIHR Group in Matrix Dynamics and Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada

Received 2 September 2005/ Returned for modification 11 October 2005/ Accepted 27 November 2005

In this study of human polymorphonuclear leukocytes (PMNs), pretreatment with Treponema denticola major outer sheath protein (Msp) inhibited formyl-methionyl-leucyl-phenylalanine (fMLP)-induced chemotaxis, phagocytosis of immunoglobulin G-coated microspheres, fMLP-stimulated calcium transients, and actin assembly. Msp neither altered oxidative responses to phorbol myristate or fMLP nor induced apoptosis. Msp selectively impairs chemotaxis and phagocytosis by impacting the PMN cytoskeleton.

* Corresponding author. Mailing address: 243 Fitzgerald Building, 150 College Street, University of Toronto, Toronto, Ontario, Canada M5S 3E2. Phone: (416) 978-6685. Fax: (416) 978-5956. E-mail: michael.glogauer{at}utoronto.ca.

Editor: J. B. Bliska

{dagger} M.G. and R.P.E. are both principal authors.

Infection and Immunity, March 2006, p. 1954-1957, Vol. 74, No. 3
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.3.1954-1957.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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