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Infection and Immunity, April 2006, p. 2446-2448, Vol. 74, No. 4
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.4.2446-2448.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Active Immunization against Pneumocystis carinii with a Recombinant P. carinii Antigen

Jesse Wells,1 Constantine G. Haidaris,1 Terry W. Wright,1,2 and Francis Gigliotti1,2*

Departments of Microbiology and Immunology,1 Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 146422

Received 29 December 2005/ Returned for modification 31 December 2005/ Accepted 11 January 2006

Mice immunized with recombinant mouse Pneumocystis carinii antigen A12-thiredoxin fusion protein developed an antibody response that recognized P. carinii antigens, as determined by Western blotting and immunofluorescence analysis. Compared to mice immunized with thioredoxin alone, mice immunized with A12-thioredoxin had significantly reduced lung P. carinii burdens after CD4+ T-cell depletion and challenge with P. carinii.

* Corresponding author. Mailing address: Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Box 690, 601 Elmwood Ave., Rochester, NY 14642. Phone: (585) 275-5944. Fax: (585) 273-1104. E-mail: Francis_Gigliotti{at}urmc.rochester.edu.

Editor: A. Casadevall

Infection and Immunity, April 2006, p. 2446-2448, Vol. 74, No. 4
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.4.2446-2448.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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