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Infection and Immunity, April 2006, p. 2491-2494, Vol. 74, No. 4
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.4.2491-2494.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Temporal Distribution and Parasite Load Kinetics in Blood and Tissues during Neospora caninum Infection in Mice

Esther Collantes-Fernández, Inmaculada López-Pérez, Gema Álvarez-García, and Luis M. Ortega-Mora*

Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain

Received 12 July 2004/ Returned for modification 4 November 2004/ Accepted 15 January 2006

The kinetics of Neospora caninum loads in mice inoculated with NC-Liv or NC-1 isolates were studied. The acute phase was characterized by parasitemia and the detection of parasite DNA in several organs, whereas during the chronic phase, the parasite was detected mainly in the brain. Mice infected with NC-Liv developed clinical signs, showing higher brain parasite burdens than NC-1-infected mice.

* Corresponding author. Mailing address: Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Ciudad Universitaria, E-28040 Madrid, Spain. Phone: 34-91-3944069. Fax: 34-91-3943844. E-mail: luis.ortega{at}vet.ucm.es.

Editor: J. F. Urban, Jr.

Infection and Immunity, April 2006, p. 2491-2494, Vol. 74, No. 4
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.4.2491-2494.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Dubey, J. P., Schares, G., Ortega-Mora, L. M. (2007). Epidemiology and Control of Neosporosis and Neospora caninum. Clin. Microbiol. Rev. 20: 323-367 [Abstract] [Full Text]  


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