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Infection and Immunity, June 2006, p. 3347-3354, Vol. 74, No. 6
0019-9567/06/$08.00+0     doi:10.1128/IAI.01724-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Identification of a Novel Antigen of Schistosoma mansoni Shared with Plasmodium falciparum and Evaluation of Different Cross-Reactive Antibody Subclasses Induced by Human Schistosomiasis and Malaria

Christine Pierrot,1 Shona Wilson,2 Hélène Lallet,1 Sophia Lafitte,1 Frances M. Jones,2 Wassim Daher,1 Monique Capron,1 David W. Dunne,2* and Jamal Khalife1*

Unité Inserm 547, IFR 17, Institut Pasteur de Lille, 1 rue du Prof. Calmette, 59019 Lille, France,1 Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, United Kingdom2

Received 21 October 2005/ Returned for modification 17 January 2006/ Accepted 7 March 2006

Plasmodium falciparum and Schistosoma mansoni are often found in human coinfections, and cross-reactive antibodies to different components of the two parasites have been detected. In this work, we identified a cross-reactive S. mansoni gene product, referred to as SmLRR, that seems to belong to the leucine-rich repeat protein family. Comparative analysis of SmLRR revealed 57% similarity with a putative gene product encoded in the P. falciparum genome. Antibodies to SmLRR were found in experimental infections and in both S. mansoni- and P. falciparum-infected individuals. Correlative analysis of human anti-SmLRR responses in Kenya and Uganda suggested that malaria and schistosomiasis drive the immunoglobulin G3 (IgG3) and IgG4 isotypes, respectively, against SmLRR, suggesting that there is differential regulation of cross-reactive isotypes depending on the infection. In addition, the levels of anti-SmLRR IgG4, but not the levels of IgG3, correlated positively with the intensity of S. mansoni infection.

* Corresponding author. Mailing address for Jamal Khalife: Unité Inserm 547, IFR 17, Institut Pasteur de Lille, 1 rue du Prof. Calmette, 59019 Lille, France. Phone: (33) 320877968. Fax: (33) 320877888. E-mail: jamal.khalife{at}pasteur-lille.fr. Mailing address for David W. Dunne: Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, United Kingdom. Phone: (44) 1223333336. Fax: (44) 1223333741. E-mail: dd{at}mole.bio.cam.ac.uk.

Editor: J. F. Urban, Jr.

Infection and Immunity, June 2006, p. 3347-3354, Vol. 74, No. 6
0019-9567/06/$08.00+0     doi:10.1128/IAI.01724-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • McManus, D. P., Loukas, A. (2008). Current Status of Vaccines for Schistosomiasis. Clin. Microbiol. Rev. 21: 225-242 [Abstract] [Full Text]  


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