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Infection and Immunity, July 2006, p. 4370-4374, Vol. 74, No. 7
0019-9567/06/$08.00+0     doi:10.1128/IAI.00422-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Responses to Leishmania donovani in Mice Deficient in Interleukin-12 (IL-12), IL-12/IL-23, or IL-18

Henry W. Murray,1* Christine W. Tsai,1 Jianguo Liu,2 and Xiaojing Ma2

Departments of Medicine,1 Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 100212

Received 15 March 2006/ Returned for modification 19 April 2006/ Accepted 21 April 2006

Interleukin-12 (IL-12) orchestrates acquired resistance in intracellular Leishmania donovani infection in the liver, inducing gamma interferon and, in turn, macrophage activation and parasite killing. Nevertheless, testing in IL-18–/– mice compared to wild-type mice and in IL-12p40–/– compared to IL-12p35–/– mice also suggested both early-acting (IL-18) and late-acting (IL-23) antileishmanial effects independent of IL-12.

* Corresponding author. Mailing address: Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021. Phone: (212) 746-6330. Fax: (212) 746-6332. E-mail: hwmurray{at}med.cornell.edu.

Editor: W. A. Petri, Jr.

Infection and Immunity, July 2006, p. 4370-4374, Vol. 74, No. 7
0019-9567/06/$08.00+0     doi:10.1128/IAI.00422-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Murray, H. W. (2008). Accelerated Control of Visceral Leishmania donovani Infection in Interleukin-6-Deficient Mice. Infect. Immun. 76: 4088-4091 [Abstract] [Full Text]  
  • McFarlane, E., Perez, C., Charmoy, M., Allenbach, C., Carter, K. C., Alexander, J., Tacchini-Cottier, F. (2008). Neutrophils Contribute to Development of a Protective Immune Response during Onset of Infection with Leishmania donovani. Infect. Immun. 76: 532-541 [Abstract] [Full Text]  
  • Maroof, A., Kaye, P. M. (2008). Temporal Regulation of Interleukin-12p70 (IL-12p70) and IL-12-Related Cytokines in Splenic Dendritic Cell Subsets during Leishmania donovani Infection. Infect. Immun. 76: 239-249 [Abstract] [Full Text]  


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