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Infection and Immunity, August 2006, p. 4915-4917, Vol. 74, No. 8
0019-9567/06/$08.00+0     doi:10.1128/IAI.00283-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Murine Model of Infection by Tropheryma whipplei

Séverine Genot,1 Andreas Stein,1 Hubert Lepidi,1 Melanie Ihrig,2 Didier Raoult,1 and Jean-Louis Mege1*

Unité des Rickettsies, CNRS UMR 6020, Faculté de Médecine, Université de la Méditerranée, Marseille, France,1 Department of Veterinary Pathology, College of Veterinary Medicine, Texas A&M University, College Station, Texas 778432

Received 21 February 2006/ Returned for modification 10 April 2006/ Accepted 25 May 2006

We developed an animal model reproducing several aspects of Whipple's disease. Immunocompetent mice were persistently infected with Tropheryma whipplei, its etiological agent, and developed liver granulomas. SCID mice were infected similarly but did not develop tissue lesions. The delayed clearance of T. whipplei suggests a protective role for innate immunity.

* Corresponding author. Mailing address: Unité des Rickettsies, Faculté de Médecine, Univ. de la Méditerranée, 27 Bld. Jean Moulin, 13385 Marseille Cedex 05, France. Phone: (33) 4 91 32 43 75. Fax: (33) 4 91 38 77 72. E-mail: Jean-Louis.Mege{at}medecine.univ-mrs.fr.

Editor: J. L. Flynn

Infection and Immunity, August 2006, p. 4915-4917, Vol. 74, No. 8
0019-9567/06/$08.00+0     doi:10.1128/IAI.00283-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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