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Infection and Immunity, September 2006, p. 5397-5401, Vol. 74, No. 9
0019-9567/06/$08.00+0     doi:10.1128/IAI.00332-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Pulmonary Lymphatics Are Primary Sites of Mycobacterium tuberculosis Infection in Guinea Pigs Infected by Aerosol

Randall J. Basaraba,* Erin E. Smith, Crystal A. Shanley, and Ian M. Orme

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523

Received 28 February 2006/ Returned for modification 28 March 2006/ Accepted 7 June 2006

Mycobacterium tuberculosis causes a lymphatic vasculitis in the lungs of guinea pigs infected by a low-dose aerosol. This observation suggests that in addition to being a direct conduit from the lungs to the regional lymph nodes, pulmonary lymphatics are themselves sites of infection and could be the site of latent infection.

* Corresponding author. Mailing address: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523-1619. Phone: (970) 491-3313. Fax: (970) 491-0603. E-mail: basaraba{at}colostate.edu.

Editor: J. L. Flynn

Infection and Immunity, September 2006, p. 5397-5401, Vol. 74, No. 9
0019-9567/06/$08.00+0     doi:10.1128/IAI.00332-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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  • Hoff, D. R., Caraway, M. L., Brooks, E. J., Driver, E. R., Ryan, G. J., Peloquin, C. A., Orme, I. M., Basaraba, R. J., Lenaerts, A. J. (2008). Metronidazole Lacks Antibacterial Activity in Guinea Pigs Infected with Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 52: 4137-4140 [Abstract] [Full Text]  
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