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Infection and Immunity, September 2006, p. 5419-5421, Vol. 74, No. 9
0019-9567/06/$08.00+0     doi:10.1128/IAI.00739-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

N-Acetyllactosamine Conjugated to Gold Nanoparticles Inhibits Enteropathogenic Escherichia coli Colonization of the Epithelium in Human Intestinal Biopsy Specimens

Romney M. Hyland,1 Paul Beck,2 George L. Mulvey,1 Pavel I. Kitov,3 and Glen D. Armstrong1*

Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, AB T2N 4N1, Canada,1 Division of Gastroenterology, University of Calgary, Calgary, AB T2N 4N1, Canada,2 Department of Chemistry, University of Alberta, Edmonton, AB T6G 2G2, Canada3

Received 8 May 2006/ Returned for modification 9 June 2006/ Accepted 14 June 2006

We previously reported that the bundle-forming pilus-mediated localized adherence of enteropathogenic Escherichia coli to HEp-2, T84, and Caco-2 cells is inhibited by N-acetyllactosamine neoglycoconjugates. The results presented here extend this observation to the epithelium of biopsy specimens obtained from the human adult duodenum, terminal ileum, and colon.

* Corresponding author. Mailing address: Department of Microbiology & Infectious Diseases, Faculty of Medicine, University of Calgary, 3330 Hospital Drive, NW, Calgary, AB T2N 4N1, Canada. Phone: (403) 220-6885. Fax: (403) 270-2772. E-mail: glen.armstrong{at}ucalgary.ca.

Editor: A. D. O'Brien

Infection and Immunity, September 2006, p. 5419-5421, Vol. 74, No. 9
0019-9567/06/$08.00+0     doi:10.1128/IAI.00739-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Humphries, R. M., Waterhouse, C. C. M., Mulvey, G., Beck, P., Armstrong, G. D. (2009). Interactions of Enteropathogenic Escherichia coli with Pediatric and Adult Intestinal Biopsy Specimens during Early Adherence. Infect. Immun. 77: 4463-4468 [Abstract] [Full Text]  


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