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Infection and Immunity, October 2007, p. 4972-4979, Vol. 75, No. 10
0019-9567/07/$08.00+0     doi:10.1128/IAI.00763-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

The O Antigen Enables Bordetella parapertussis To Avoid Bordetella pertussis-Induced Immunity{triangledown}

Daniel N. Wolfe,1 Elizabeth M. Goebel,2 Ottar N. Bjornstad,3 Olivier Restif,4 and Eric T. Harvill1*

Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, 115 Henning Building, University Park, Pennsylvania 16802,1 Huck Institute of Life Sciences, The Pennsylvania State University, 519 Wartik Lab, University Park, Pennsylvania 16802,2 Departments of Entomology and Biology, The Pennsylvania State University, 501 Agricultural Sciences and Industry Building, University Park, Pennsylvania 16802,3 Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, Great Britain4

Received 5 June 2007/ Returned for modification 18 July 2007/ Accepted 1 August 2007

Bordetella pertussis and Bordetella parapertussis are closely related endemic human pathogens which cause whooping cough, a disease that is reemerging in human populations. Despite how closely related these pathogens are, their coexistence and the limited efficacy of B. pertussis vaccines against B. parapertussis suggest a lack of cross-protective immunity between the two. We sought to address the ability of infection-induced immunity against one of these pathogens to protect against subsequent infection by the other using a mouse model of infection. Immunity induced by B. parapertussis infection protected against subsequent infections by either species. However, immunity induced by B. pertussis infection prevented subsequent B. pertussis infections but did not protect against B. parapertussis infections. The O antigen of B. parapertussis inhibited binding of antibodies to the bacterial surface and was required for B. parapertussis to colonize mice convalescent from B. pertussis infection. Thus, the O antigen of B. parapertussis confers asymmetrical cross-immunity between the causative agents of whooping cough. We propose that these findings warrant investigation of the relative role of B. parapertussis in the resurgence of whooping cough.

* Corresponding author. Mailing address: Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, 115 Henning Building, University Park, PA 16802. Phone: (814) 863-8522. Fax: (814) 863-6140. E-mail: harvill{at}psu.edu

{triangledown} Published ahead of print on 13 August 2007.

Editor: D. L. Burns

Infection and Immunity, October 2007, p. 4972-4979, Vol. 75, No. 10
0019-9567/07/$08.00+0     doi:10.1128/IAI.00763-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Zhang, X., Goebel, E. M., Rodriguez, M. E., Preston, A., Harvill, E. T. (2009). The O Antigen Is a Critical Antigen for the Development of a Protective Immune Response to Bordetella parapertussis. Infect. Immun. 77: 5050-5058 [Abstract] [Full Text]  
  • Skerry, C. M., Cassidy, J. P., English, K., Feunou-Feunou, P., Locht, C., Mahon, B. P. (2009). A Live Attenuated Bordetella pertussis Candidate Vaccine Does Not Cause Disseminating Infection in Gamma Interferon Receptor Knockout Mice. CVI 16: 1344-1351 [Abstract] [Full Text]  
  • Buboltz, A. M., Nicholson, T. L., Karanikas, A. T., Preston, A., Harvill, E. T. (2009). Evidence for Horizontal Gene Transfer of Two Antigenically Distinct O Antigens in Bordetella bronchiseptica. Infect. Immun. 77: 3249-3257 [Abstract] [Full Text]  
  • Goebel, E. M., Wolfe, D. N., Elder, K., Stibitz, S., Harvill, E. T. (2008). O Antigen Protects Bordetella parapertussis from Complement. Infect. Immun. 76: 1774-1780 [Abstract] [Full Text]  


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