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Infection and Immunity, November 2007, p. 5118-5126, Vol. 75, No. 11
0019-9567/07/$08.00+0     doi:10.1128/IAI.00334-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Expression of Helicobacter pylori Virulence Factors and Associated Expression Profiles of Inflammatory Genes in the Human Gastric Mucosa{triangledown}

Sicheng Wen,1 Dominique Velin,2 Christian P. Felley,2 Likun Du,1 Pierre Michetti,2 and Qiang Pan-Hammarström1*

Division of Clinical Immunology, Department of Laboratory Medicine, F79, Karolinska University Hospital Huddinge, Karolinska Institutet, SE-141 86, Stockholm, Sweden,1 Department of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland2

Received 2 March 2007/ Returned for modification 22 April 2007/ Accepted 8 August 2007

Helicobacter pylori virulence factors have been suggested to be important in determining the outcome of infection. The H. pylori adhesion protein BabA2 is thought to play a crucial role in bacterial colonization and in induction of severe gastric inflammation, particularly in combination with expression of CagA and VacA. However, the influence of these virulence factors on the pathogenesis of H. pylori infection is still poorly understood. To address this question, the inflammatory gene expression profiles for two groups of patients infected with triple-negative strains (lacking expression of cagA, babA2, and vacAs1 but expressing vacAs2) and triple-positive strains (expressing cagA, vacAs1, and babA2 but lacking expression of vacAs2) were investigated. The gene expression patterns in the antrum gastric mucosa from patients infected with different H. pylori strains were very similar, and no differentially expressed genes could be identified by pairwise comparisons. Our data thus suggest that there is a lack of correlation between the host inflammatory responses in the gastric mucosa and expression of the babA2, cagA, and vacAs1 genes.

* Corresponding author. Mailing address: Division of Clinical Immunology, Department of Laboratory Medicine, F79, Karolinska University Hospital Huddinge, SE-141 86, Stockholm, Sweden. Phone: 46 8 52483592. Fax: 46 8 52483588. E-mail: Qiang.Pan-Hammarstrom{at}ki.se

{triangledown} Published ahead of print on 20 August 2007.

Editor: A. Camilli

Infection and Immunity, November 2007, p. 5118-5126, Vol. 75, No. 11
0019-9567/07/$08.00+0     doi:10.1128/IAI.00334-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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