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Infection and Immunity, February 2007, p. 1055-1058, Vol. 75, No. 2
0019-9567/07/$08.00+0     doi:10.1128/IAI.00835-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Hypervirulence of a Rough Variant of the Mycobacterium abscessus Type Strain{triangledown}

E. Catherinot,1 J. Clarissou,2 G. Etienne,3 F. Ripoll,1 J.-F. Emile,4 M. Daffé,3 C. Perronne,2 C. Soudais,5 J.-L. Gaillard,1 and M. Rottman1*

Laboratoire de Microbiologie,1 Département de Médecine Aiguë Spécialisée, Hôpital R. Poincaré (AP-HP) and Université de Versailles-Saint Quentin—Faculté de Médecine Paris-Ile de France-Ouest, 92380 Garches,2 Institut de Pharmacologie et de Biologie Structurale du CNRS—UMR 5089, Département "Mécanismes Moléculaires des Infections Mycobactériennes," 205 route de Narbonne, 31077 Toulouse Cedex,3 Laboratoire d'Anatomo-Pathologie, Hôpital A. Paré (AP-HP), 92100 Boulogne,4 Unité d'Immunologie et d'Hématologie, Hôpital Necker-Enfants Malades (AP-HP) and Laboratory of Human Genetics of Infectious Diseases, Université René Descartes—INSERM U550, Faculté de Médecine Necker-Enfants Malades, 75730 Paris Cedex 15, France5

Received 24 May 2005/ Returned for modification 16 August 2006/ Accepted 30 November 2006

We isolated a rough variant of Mycobacterium abscessus CIP 104536T during experimental infection of mice. We show that this variant has lost the ability to produce glycopeptidolipids, is hyperlethal for C57BL/6 mice infected intravenously, and induces a strong tumor necrosis factor-alpha response by murine monocyte-derived macrophages.

* Corresponding author. Mailing address: Laboratoire de Microbiologie, Hôpital Raymond Poincaré, 104 Bd Raymond Poincaré, 92380 Garches, France. Phone: 33.1.47.10.46.22. Fax: 33.1.47.10.79.49. E-mail: martin.rottman{at}rpc.aphp.fr.

{triangledown} Published ahead of print on 4 December 2006.

Editor: J. L. Flynn

Infection and Immunity, February 2007, p. 1055-1058, Vol. 75, No. 2
0019-9567/07/$08.00+0     doi:10.1128/IAI.00835-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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