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Infection and Immunity, March 2007, p. 1502-1506, Vol. 75, No. 3
0019-9567/07/$08.00+0     doi:10.1128/IAI.01801-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Selection for Simple Major Surface Protein 2 Variants during Anaplasma marginale Transmission to Immunologically Naïve Animals{triangledown}

Guy H. Palmer,1* James E. Futse,1 Christina K. Leverich,1 Donald P. Knowles Jr.,2 Fred R. Rurangirwa,1 and Kelly A. Brayton1

Program in Vector-borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University,1 Animal Diseases Research Unit, Agricultural Research Service, U.S. Department of Agriculture, Pullman, Washington2

Received 10 November 2006/ Returned for modification 1 December 2006/ Accepted 7 December 2006

Anaplasma marginale, a rickettsial pathogen, evades clearance in the animal host by antigenic variation. Under immune selection, A. marginale expresses complex major surface protein 2 mosaics, derived from multiple donor sequences. However, these mosaics have a selective advantage only in the presence of adaptive immunity and are rapidly replaced by simple variants following transmission.

* Corresponding author. Mailing address: Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040. Phone: (509) 335-6033. Fax: (509) 335-8529. E-mail: gpalmer{at}vetmed.wsu.edu.

{triangledown} Published ahead of print on 18 December 2006.

Editor: R. P. Morrison

Infection and Immunity, March 2007, p. 1502-1506, Vol. 75, No. 3
0019-9567/07/$08.00+0     doi:10.1128/IAI.01801-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Futse, J. E., Brayton, K. A., Nydam, S. D., Palmer, G. H. (2009). Generation of Antigenic Variants via Gene Conversion: Evidence for Recombination Fitness Selection at the Locus Level in Anaplasma marginale. Infect. Immun. 77: 3181-3187 [Abstract] [Full Text]  
  • Sarkar, M., Troese, M. J., Kearns, S. A., Yang, T., Reneer, D. V., Carlyon, J. A. (2008). Anaplasma phagocytophilum MSP2(P44)-18 Predominates and Is Modified into Multiple Isoforms in Human Myeloid Cells. Infect. Immun. 76: 2090-2098 [Abstract] [Full Text]  
  • Zhuang, Y., Futse, J. E., Brown, W. C., Brayton, K. A., Palmer, G. H. (2007). Maintenance of Antibody to Pathogen Epitopes Generated by Segmental Gene Conversion Is Highly Dynamic during Long-Term Persistent Infection. Infect. Immun. 75: 5185-5190 [Abstract] [Full Text]  


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