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Infection and Immunity, March 2007, p. 1507-1511, Vol. 75, No. 3
0019-9567/07/$08.00+0     doi:10.1128/IAI.01326-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Toll-Like Receptor-2-Mediated C-C Chemokine Receptor 3 and Eotaxin-Driven Eosinophil Influx Induced by Mycobacterium bovis BCG Pleurisy{triangledown}

Heloisa D'Ávila, Patrícia E. Almeida, Natália R. Roque, Hugo C. Castro-Faria-Neto, and Patrícia T. Bozza*

Laboratório de Imunofarmacologia, Departamento de Fisiologia e Farmacodinâmica, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21045-900, Brazil

Received 18 August 2006/ Returned for modification 15 September 2006/ Accepted 1 December 2006

An acute and persistent eosinophil infiltration is observed during Mycobacterium bovis BCG pleural infection in mice. Eosinophil accumulation, lipid body formation, and eotaxin production were significantly reduced in BCG-infected Toll-like receptor-2 (TLR2)-deficient mice compared to wild-type mice. Neutralization of eotaxin or CCR3 drastically inhibited BCG-induced eosinophil accumulation and lipid body formation, indicating that BCG-induced eosinophil recruitment and activation is largely dependent of TLR2-mediated eotaxin generation.

* Corresponding author. Mailing address: Laboratório de Imunofarmacologia, Departamento de Fisiologia e Farmacodinâmica, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil 4365, Manguinhos, Rio de Janeiro 21045-900, Brazil. Phone: 55-21-2598-4492, x221. Fax: 55-21-2590-9490. E-mail: pbozza{at}ioc.fiocruz.br.

{triangledown} Published ahead of print on 11 December 2006.

Editor: J. L. Flynn

Infection and Immunity, March 2007, p. 1507-1511, Vol. 75, No. 3
0019-9567/07/$08.00+0     doi:10.1128/IAI.01326-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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