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Infection and Immunity, April 2007, p. 2079-2083, Vol. 75, No. 4
0019-9567/07/$08.00+0     doi:10.1128/IAI.01685-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

The SAG1 Toxoplasma gondii Surface Protein Is Not Required for Acute Ocular Toxoplasmosis in Mice{triangledown}

Elizabeth Charles,1 Michelle C. Callegan,1,2 and Ira J. Blader1*

Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104,1 Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 731042

Received 20 October 2006/ Returned for modification 4 January 2007/ Accepted 28 January 2007

The SAG1 Toxoplasma gondii surface protein stimulates acute ileitis. To determine whether SAG1 is also important in the eye, wild-type or SAG1 knockout parasites were injected intravitreally into mice. No differences in retinal damage or parasite growth were observed, indicating that unlike the case for the intestine, factors besides SAG1 are important for retinal damage.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, 940 Stanton L. Young Blvd., BMSB 1034, Oklahoma City, OK 73034. Phone: (405) 271-2133. Fax: (405) 271-3117. E-mail: iblader{at}ouhsc.edu.

{triangledown} Published ahead of print on 5 February 2007.

Editor: J. L. Flynn

Infection and Immunity, April 2007, p. 2079-2083, Vol. 75, No. 4
0019-9567/07/$08.00+0     doi:10.1128/IAI.01685-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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