This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ekkens, M. J.
Right arrow Articles by Pearce, E. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ekkens, M. J.
Right arrow Articles by Pearce, E. J.

 Previous Article  |  Next Article 

Infection and Immunity, May 2007, p. 2291-2296, Vol. 75, No. 5
0019-9567/07/$08.00+0     doi:10.1128/IAI.01328-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Th1 and Th2 Cells Help CD8 T-Cell Responses{triangledown}

Melinda J. Ekkens,1,{dagger} Devon J. Shedlock,2,{ddagger} EuiHye Jung,1 Amy Troy,2,§ Erika L. Pearce,2,|| Hao Shen,1 and Edward J. Pearce1*

Department of Pathobiology, School of Veterinary Medicine,1 Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 190142

Received 18 August 2006/ Returned for modification 30 September 2006/ Accepted 12 February 2007

Help from CD4 T cells is often important for the establishment of primary and memory CD8 T-cell responses. However, it has yet to be determined whether T helper polarization affects the delivery of help and/or whether responding CD8 T cells helped by Th1 or Th2 cells express distinct effector properties. To address these issues, we compared CD8 T-cell responses in the context of Th1 or Th2 help by injecting dendritic cells copulsed with the major histocompatibility complex class I-restricted OVA peptide plus, respectively, bacterial or helminth antigens. We found that Th2 cells, like Th1 cells, can help primary and long-lived memory CD8 T-cell responses. Experiments in interleukin-12 (IL-12)–/– and IL-4–/– mice, in which polarized Th1 or Th2 responses, respectively, fail to develop, indicate that the underlying basis of CD4 help is independent of attributes acquired as a response to polarization.

* Corresponding author. Mailing address: Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, 380 South University Ave., Philadelphia, PA 19104-4593. Phone: (215) 573-3493. Fax: (215) 746-2995. E-mail: ejpearce{at}mail.med.upenn.edu

{triangledown} Published ahead of print on 26 February 2007.

Editor: J. F. Urban, Jr.

{dagger} Present address: Department of Biology, Columbia Union College, Takoma Park, MD.

{ddagger} Present address: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

§ Present address: Department of Pathology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.

|| Present address: Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

Infection and Immunity, May 2007, p. 2291-2296, Vol. 75, No. 5
0019-9567/07/$08.00+0     doi:10.1128/IAI.01328-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Jing, L., Davies, D. H., Chong, T. M., Chun, S., McClurkan, C. L., Huang, J., Story, B. T., Molina, D. M., Hirst, S., Felgner, P. L., Koelle, D. M. (2008). An Extremely Diverse CD4 Response to Vaccinia Virus in Humans Is Revealed by Proteome-Wide T-Cell Profiling. J. Virol. 82: 7120-7134 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»