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Infection and Immunity, May 2007, p. 2630-2633, Vol. 75, No. 5
0019-9567/07/$08.00+0     doi:10.1128/IAI.01836-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Gamma Interferon Suppresses Erythropoiesis via Interleukin-15{triangledown}

Isis K. Mullarky,* Frank M. Szaba, Lawrence W. Kummer, Lindsey B. Wilhelm, Michelle A. Parent, Lawrence L. Johnson, and Stephen T. Smiley

Trudeau Institute, Saranac Lake, New York

Received 20 November 2006/ Returned for modification 2 January 2007/ Accepted 10 February 2007

Impaired erythropoiesis causes anemia during genetic disorders, chronic disease, and infection. In studies of the underlying mechanisms researchers have increasingly focused on gamma interferon (IFN-{gamma}). Here, we identified a previously unrecognized role for interleukin-15 (IL-15) in red blood cell homeostasis and demonstrated that IFN-{gamma} and signal transducer and activator of transcription protein 1-dependent pathways up-regulate expression of IL-15 in vivo. These findings identified new therapeutic targets for anemia.

* Corresponding author. Present address: Department of Dairy Science, Virginia Polytechnic Institute and State University, 2470 Litton-Reaves Hall, Blacksburg, VA 24061. Phone: (540) 231-2410. Fax: (540) 231-5014. E-mail: mullarky{at}vt.edu

{triangledown} Published ahead of print on 16 February 2007.

Editor: J. F. Urban, Jr.

Infection and Immunity, May 2007, p. 2630-2633, Vol. 75, No. 5
0019-9567/07/$08.00+0     doi:10.1128/IAI.01836-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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