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Infection and Immunity, June 2007, p. 3178-3182, Vol. 75, No. 6
0019-9567/07/$08.00+0     doi:10.1128/IAI.01811-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

An In Vitro Model System Used To Study Adherence and Invasion of Francisella tularensis Live Vaccine Strain in Nonphagocytic Cells{triangledown}

Stephen R. Lindemann, Molly K. McLendon, Michael A. Apicella, and Bradley D. Jones*

Department of Microbiology, Roy J. and Lucille A. Carver School of Medicine, University of Iowa, Iowa City, Iowa 52242

Received 14 November 2006/ Returned for modification 21 December 2006/ Accepted 26 February 2007

In observing Francisella tularensis interactions with nonphagocytic cell lines in vitro, we noted significant adherence, invasion, and intracellular growth of the bacteria within these cells. F. tularensis live vaccine strain invasion of nonprofessional phagocytic cells is inhibited by cytochalasin D and nocodazole, suggesting that both the actin and microtubule cytoskeletons are important for invasion.

* Corresponding author. Mailing address: Department of Microbiology, University of Iowa School of Medicine, 51 Newton Road, Iowa City, IA 52242-1109. Phone: (319) 353-5457. Fax: (319) 335-9006. E-mail: bradley-jones{at}uiowa.edu

{triangledown} Published ahead of print on 5 March 2007.

Editor: J. B. Bliska

Infection and Immunity, June 2007, p. 3178-3182, Vol. 75, No. 6
0019-9567/07/$08.00+0     doi:10.1128/IAI.01811-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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