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Infection and Immunity, June 2007, p. 3188-3191, Vol. 75, No. 6
0019-9567/07/$08.00+0     doi:10.1128/IAI.01745-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Protein F1 and Streptococcus pyogenes Resistance to Phagocytosis{triangledown}

Kendra A. Hyland,* Beinan Wang, and P. Patrick Cleary

Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455

Received 1 November 2006/ Returned for modification 24 January 2007/ Accepted 13 March 2007

Streptococcus pyogenes is a major cause of pharyngitis in humans and encodes several fibronectin-binding proteins. M protein and protein F1 (PrtF1/SfbI) are differentially regulated by CO2 and O2, respectively, and both mediate the invasion of epithelial cells. This study examined whether PrtF1/SfbI shares other properties with M protein. Expression of the PrtF1/SfbI protein by an M-negative mutant conferred resistance to phagocytosis and partial inhibition of C3 deposition on the S. pyogenes surface.

* Corresponding author. Mailing address: Department of Microbiology, University of Minnesota Medical School, MMC196, 420 Delaware Street S.E., Minneapolis, MN 55455. Phone: (612) 624-0622. Fax: (612) 625-5203. E-mail: hyla0021{at}umn.edu

{triangledown} Published ahead of print on 19 March 2007.

Editor: J. N. Weiser

Infection and Immunity, June 2007, p. 3188-3191, Vol. 75, No. 6
0019-9567/07/$08.00+0     doi:10.1128/IAI.01745-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Yamaguchi, M., Terao, Y., Mori, Y., Hamada, S., Kawabata, S. (2008). PfbA, a Novel Plasmin- and Fibronectin-binding Protein of Streptococcus pneumoniae, Contributes to Fibronectin-dependent Adhesion and Antiphagocytosis. J. Biol. Chem. 283: 36272-36279 [Abstract] [Full Text]  


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