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Infection and Immunity, June 2007, p. 3202-3204, Vol. 75, No. 6
0019-9567/07/$08.00+0     doi:10.1128/IAI.01501-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

The Phase-Variable Allele of the Pilus Glycosylation Gene pglA Is Not Strongly Associated with Strains of Neisseria gonorrhoeae Isolated from Patients with Disseminated Gonococcal Infection{triangledown} ,{dagger}

P. M. Power,1 S. C. Ku,1 K. Rutter,1 M. J. Warren,1 E. A. Limnios,2 J. W. Tapsall,2 and M. P. Jennings1*

School of Molecular and Microbial Sciences, The University of Queensland, St. Lucia, Queensland 4072, Australia,1 Neisseria Reference Laboratory, Microbiology Department, The Prince of Wales Hospital, Barker St., Randwick, New South Wales 2031, Australia2

Received 19 September 2006/ Returned for modification 2 November 2006/ Accepted 30 January 2007

The Neisseria gonorrhoeae pglA gene has two alleles, one of which is phase variable. A previous study reported that all disseminated gonococcal infection (DGI) isolates contained the phase-variable allele and proposed a causal link. In the present study of 81 strains no absolute correlation between DGI and the phase-variable pglA allele was observed.

* Corresponding author. Mailing address: School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, QLD 4072, Australia. Phone: 61 7 3365 4879. Fax: 61 7 3365 4620. E-mail: jennings{at}uq.edu.au

{triangledown} Published ahead of print on 12 February 2007.

{dagger} Supplemental material for this article may be found at http://iai.asm.org./.

Editor: J. N. Weiser

Infection and Immunity, June 2007, p. 3202-3204, Vol. 75, No. 6
0019-9567/07/$08.00+0     doi:10.1128/IAI.01501-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Whiley, D. M., Limnios, E. A., Ray, S., Sloots, T. P., Tapsall, J. W. (2007). Diversity of penA Alterations and Subtypes in Neisseria gonorrhoeae Strains from Sydney, Australia, That Are Less Susceptible to Ceftriaxone. Antimicrob. Agents Chemother. 51: 3111-3116 [Abstract] [Full Text]  


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