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Infection and Immunity, July 2007, p. 3462-3469, Vol. 75, No. 7
0019-9567/07/$08.00+0     doi:10.1128/IAI.01470-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Possible Correlates of Long-Term Protection against Helicobacter pylori following Systemic or Combinations of Mucosal and Systemic Immunizations{triangledown}

Jennifer M. Taylor, Melanie E. Ziman, Julie Fong, Jay V. Solnick, and Michael Vajdy*

Departments of Internal Medicine and Medical Microbiology and Immunology, Center for Comparative Medicine, University of California, Davis, Davis, California

Received 13 September 2006/ Returned for modification 26 November 2006/ Accepted 2 May 2007

The ability to induce long-term immunity to Helicobacter pylori is necessary for an effective vaccine. This study was designed to establish the most efficient route(s) (systemic, mucosal, or a combination) of immunization for induction of long-term immunity and to define correlates of protection. Mice were immunized orally alone (oral group), intramuscularly (i.m.) alone (i.m. group), orally followed by i.m. (oral/i.m. group), or i.m. followed by orally (i.m./oral group). Long-term protective immunity to oral H. pylori challenge was observed 3 months after immunization through the i.m. or oral/i.m. route. Protection correlated with an increase in H. pylori-specific interleukin-12 and both immunoglobulin G1 (IgG1) and IgG2a serum titers following challenge. Mice that were not protected (oral or i.m./oral) had increased levels of IgA in both sera and Peyer's patches. This study demonstrates the ability to induce long-term immunity against H. pylori, provides correlates of protection, and illustrates the crucial role of the immunization route(s).

* Corresponding author. Mailing address: Departments of Internal Medicine and Medical Microbiology and Immunology, Center for Comparative Medicine, University of California, Davis, Davis, CA 95616. Phone: (510) 923-8595. Fax: (510) 655-9910. E-mail: Michael_Vajdy{at}chiron.com

{triangledown} Published ahead of print on 14 May 2007.

Editor: V. J. DiRita

Infection and Immunity, July 2007, p. 3462-3469, Vol. 75, No. 7
0019-9567/07/$08.00+0     doi:10.1128/IAI.01470-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Zhou, F., Goodsell, A., Uematsu, Y., Vajdy, M. (2009). Prolonged Protection against Intranasal Challenge with Influenza Virus following Systemic Immunization or Combinations of Mucosal and Systemic Immunizations with a Heat-Labile Toxin Mutant. CVI 16: 471-478 [Abstract] [Full Text]  


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