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Infection and Immunity, November 2008, p. 4851-4858, Vol. 76, No. 11
0019-9567/08/$08.00+0     doi:10.1128/IAI.00745-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Modulation of Acute Diarrheal Illness by Persistent Bacterial Infection{triangledown}

Megan E. McBee,1 Patricia Z. Zheng,1 Arlin B. Rogers,2 James G. Fox,1,2 and David B. Schauer1,2*

Department of Biological Engineering,1 Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 021392

Received 12 June 2008/ Returned for modification 25 July 2008/ Accepted 11 August 2008

Acute diarrheal illness is a global health problem that may be exacerbated by concurrent infection. Using Citrobacter rodentium, a murine model of attaching and effacing diarrheagenic Escherichia coli, we demonstrate that persistent Helicobacter hepaticus infection modulates host responses to diarrheal disease, resulting in delayed recovery from weight loss and from tissue damage. Chronic colitis in concurrently infected mice is characterized by macrophage and Foxp3+ regulatory T-cell accumulation. Prolonged disease is also associated with increased interleukin-17 expression, which may be due to suppression of gamma interferon during the acute phase of diarrheal infection. This new model of polymicrobial infection provides insight into the mechanism by which subclinical infection can exacerbate morbidity due to an unrelated self-limiting infection.

* Corresponding author. Mailing address: Department of Biological Engineering, Room 56-787B, Cambridge, MA 02139. Phone: (617) 253-8113. Fax: (617) 258-0225. E-mail: schauer{at}mit.edu

{triangledown} Published ahead of print on 18 August 2008.

Editor: B. A. McCormick

Infection and Immunity, November 2008, p. 4851-4858, Vol. 76, No. 11
0019-9567/08/$08.00+0     doi:10.1128/IAI.00745-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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