IAI Accepts, published online ahead of print on 17 March 2008
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Quenee, L. E.
Right arrow Articles by Schneewind, O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Quenee, L. E.
Right arrow Articles by Schneewind, O.

 Previous Article  |  Next Article 

Infect. Immun. doi:10.1128/IAI.00105-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Yersinia pestis caf1 (F1) Variants and the Limits of Plague Vaccine Protection

Lauriane E. Quenee, Claire A. Cornelius, Nancy A. Ciletti, Derek Elli, and Olaf Schneewind*

Department of Microbiology, University of Chicago, Chicago, IL 60637, USA

* To whom correspondence should be addressed. Email: oschnee{at}bsd.uchicago.edu.


arrow
Abstract

Yersinia pestis, the highly virulent agent of plague, is a biological weapon. Strategies that prevent plague have been sought for centuries and immunization with live-attenuated (non-pigmented) strains or subunit vaccines with F1 (Caf1) antigen are considered effective. We show here that immunization with live-attenuated strains generates plague protective immunity and humoral immune responses against F1 pilus antigen and LcrV. Y. pestis variants lacking caf1 (F1 pili) are not only fully virulent in animal models of bubonic and pneumonic plague but also break through immune responses generated with live-attenuated strains or F1 subunit vaccines. In contrast, immunization with purified LcrV, a protein at the tip of type III needles, generates protective immunity against the wild-type and the fully virulent caf1 mutant strain, in agreement with the notion that LcrV can elicit vaccine protection against both types of virulent plague strains.




This article has been cited by other articles:

  • Li, B., Zhou, L., Guo, J., Wang, X., Ni, B., Ke, Y., Zhu, Z., Guo, Z., Yang, R. (2009). High-Throughput Identification of New Protective Antigens from a Yersinia pestis Live Vaccine by Enzyme-Linked Immunospot Assay. Infect. Immun. 77: 4356-4361 [Abstract] [Full Text]  
  • Cornelius, C. A., Quenee, L. E., Elli, D., Ciletti, N. A., Schneewind, O. (2009). Yersinia pestis IS1541 Transposition Provides for Escape from Plague Immunity. Infect. Immun. 77: 1807-1816 [Abstract] [Full Text]  
  • Anderson, D. M., Ciletti, N. A., Lee-Lewis, H., Elli, D., Segal, J., DeBord, K. L., Overheim, K. A., Tretiakova, M., Brubaker, R. R., Schneewind, O. (2009). Pneumonic Plague Pathogenesis and Immunity in Brown Norway Rats. Am. J. Pathol. 174: 910-921 [Abstract] [Full Text]  
  • Cornelius, C. A., Quenee, L. E., Overheim, K. A., Koster, F., Brasel, T. L., Elli, D., Ciletti, N. A., Schneewind, O. (2008). Immunization with Recombinant V10 Protects Cynomolgus Macaques from Lethal Pneumonic Plague. Infect. Immun. 76: 5588-5597 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»