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Infect. Immun. doi:10.1128/IAI.00159-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Heterogeneity of a Campylobacter jejuni protein that is secreted through the flagella filament

Enteric Diseases Dept., Naval Medical Research Center, Silver Spring, MD 20910

^* To whom correspondence should be addressed. Email: guerryp{at}nmrc.navy.mil.

	Abstract

Cj0859c or FspA is a small, acidic protein of Campylobacter jejuni that is expressed by a ²⁸ promoter. Analysis of the fspA gene in 41 isolates of C. jejuni revealed two overall variants of the predicted protein, FspA1 and FspA2. Secretion of FspA occurs in broth grown bacteria and requires a minimum flagella structure. Addition of recombinant FspA2, but not FspA1, to INT407 cells in vitro resulted in rapid induction of apoptosis. These data define a novel C. jejuni virulence factor, and the observed heterogeneity among fspA alleles suggests alternate virulence potential among different strains.

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