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Infect. Immun. doi:10.1128/IAI.00732-06
Copyright (c) 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Cellular recognition of Mycobacterium ESAT-6 and katG peptides in systemic sarcoidosis

Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine; Department of Biology, Texas A and M University, College Station, TX; Department of Biostatistics, Vanderbilt University School of Medicine; Department of Preventive Medicine and Biometrics and Department of Medicine, University of Colorado at Denver & Health Sciences Center; Department of Microbiology and Immunology, Vanderbilt University School of Medicine

^* To whom correspondence should be addressed. Email: Wonder.drake{at}vanderbilt.edu,

	Abstract

Sarcoidosis is an enigmatic disease with pathology similar to tuberculosis. We detected Th-1 immune responses to Mycobacterium ESAT-6 and katG peptides from peripheral blood mononuclear cells of 15/26 sarcoidosis, 1/24 PPD- (p<0.0001, Fisher's exact test), and 7/8 PPD+ subjects (p=0.21). This finding provides immunologic links of mycobacteria to systemic sarcoidosis.

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