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Infect. Immun. doi:10.1128/IAI.00779-06
Copyright (c) 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Serologic evidence for effective production of cytolysin A (ClyA) in Salmonella enterica serovars Typhi and Paratyphi A during human infection

Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany

^* To whom correspondence should be addressed. Email: albrecht.ludwig{at}em.uni-frankfurt.de.

	Abstract

ClyA_STy and ClyA_SPaA are closely related pore-forming cytolysins of Salmonella enterica serovar Typhi and serovar Paratyphi A, whose expression is strongly repressed under standard in vitro growth conditions. We show here that human infections by these pathogens cause a specific antibody response to ClyA, indicating effective toxin production during infection.

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