This Article Full Text (PDF) Other Versions of this Article: IAI.00897-06v1 75/1/523    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ryan, A. A Articles by Triccas, J. A. Search for Related Content PubMed PubMed Citation Articles by Ryan, A. A Articles by Triccas, J. A.

 Previous Article  |  Next Article 

Infect. Immun. doi:10.1128/IAI.00897-06
Copyright (c) 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Secretion of functional Monocyte Chemotactic Protein-3 by recombinant Mycobacterium bovis BCG attenuates vaccine virulence and maintains protective efficacy against M. tuberculosis infection

Mycobacterial Research Group, Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No. 6, Newtown, NSW 2042 Australia; Discipline of Medicine; Discipline of Infectious Diseases and Immunology, University of Sydney, NSW, 2006, Australia

^* To whom correspondence should be addressed. Email: jamiet{at}infdis.usyd.edu.au.

	Abstract

A strain of Mycobacterium bovis BCG that secretes high levels of functional murine Monocyte Chemotactic Protein-3 (BCG_MCP-3) was developed. Mice vaccinated with BCG_MCP-3 displayed increased lymphocyte migration in vivo and augmented antigen-specific T cell responses compared to BCG alone. The level of protection afforded by BCG_MCP-3 was equivalent to control BCG, however immunodeficient mice infected with BCG_MCP-3 survived significantly longer than mice infected with the control BCG strain. Therefore BCG_MCP-3 may be a safer alternative than conventional BCG for vaccination of immunocompromised individuals.

This article has been cited by other articles:

• Ryan, A. A., Wozniak, T. M., Shklovskaya, E., O'Donnell, M. A., Fazekas de St. Groth, B., Britton, W. J., Triccas, J. A. (2007). Improved Protection against Disseminated Tuberculosis by Mycobacterium bovis Bacillus Calmette-Guerin Secreting Murine GM-CSF Is Associated with Expansion and Activation of APCs. J. Immunol. 179: 8418-8424 [Abstract] [Full Text]  
• Triccas, J. A., Shklovskaya, E., Spratt, J., Ryan, A. A., Palendira, U., Fazekas de StGroth, B., Britton, W. J. (2007). Effects of DNA- and Mycobacterium bovis BCG-Based Delivery of the Flt3 Ligand on Protective Immunity to Mycobacterium tuberculosis. Infect. Immun. 75: 5368-5375 [Abstract] [Full Text]