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Infect. Immun. doi:10.1128/IAI.01028-06
Copyright (c) 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

BbCRASP-1 of the Lyme disease spirochetes is expressed in humans and induces antibody responses restricted to non-denatured structural determinants

Department of Immunology, University of Heidelberg, Heidelberg, Germany; University Clinics for Dermatology and Allergology "Am Biederstein", TU München, Germany; Institute of Medical Microbiology, University Hospital of Frankfurt, Frankfurt, Germany; Metschnikoff Laboratory, Max-Planck-Institute for Immunobiology, Freiburg, Germany

^* To whom correspondence should be addressed. Email: wallich{at}uni-hd.de.

	Abstract

BbCRASP-1, the dominant factor H and FHL-1 binding protein of the Lyme disease spirochete Borrelia burgdorferi is implied in pathogen persistence and was recently reported to be non-immunogenic in man. Here we show that serum samples from Lyme disease patients contain antibodies with exclusive specificity for non-denatured structural determinants of BbCRASP-1.

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