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Infect. Immun. doi:10.1128/IAI.01326-06
Copyright (c) 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Toll-like Receptor-2 mediated CCR3/Eotaxin-driven eosinophil influx induced by Mycobacterium bovis BCG pleurisy

Laboratório de Imunofarmacologia, Departamento de Fisiologia e Farmacodinâmica, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil

^* To whom correspondence should be addressed. Email: pbozza{at}ioc.fiocruz.br.

	Abstract

An acute and persistent eosinophil infiltration is observed during Mycobacterium bovis BCG pleural infection in mice. Eosinophil accumulation, lipid body formation and eotaxin production were significantly reduced in BCG-infected TLR2-deficient compared to wild-type mice. Neutralization of eotaxin or CCR3 drastically inhibited BCG-induced eosinophil accumulation and lipid body formation, indicating that BCG-induced eosinophil recruitment and activation is largely dependent of TLR2-mediated eotaxin generation.

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