This Article Full Text (PDF) Other Versions of this Article: IAI.01328-06v1 75/5/2291    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ekkens, M. J. Articles by Pearce, E. J. Search for Related Content PubMed PubMed Citation Articles by Ekkens, M. J. Articles by Pearce, E. J.

 Previous Article  |  Next Article 

Infect. Immun. doi:10.1128/IAI.01328-06
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Th1 and Th2 cells help CD8 T cell responses

Department of Pathobiology, School of Veterinary Medicine, and Department of Microbiology, School of Medicine, University of Pennsylvania, PA 19014, USA

^* To whom correspondence should be addressed. Email: ejpearce{at}mail.med.upenn.edu.

	Abstract

Help from CD4 T cells is often important for the establishment of primary and memory CD8 T cell responses. However, it has yet to be determined whether T helper polarization affects the delivery of help, and/or whether responding CD8 T cells helped by Th1 or Th2 cells express distinct effector properties. To address these issues, we have compared CD8 T cell responses in the context of Th1 or Th2 help by injecting DCs co-pulsed with the MHC class I restricted OVA peptide plus, respectively, bacterial or helminth Ags. We have found that Th2 cells, like Th1 cells, can help primary and long-lived memory CD8 T cell responses. Experiments in IL-12-/- and IL-4-/- mice, in which polarized Th1 or Th2 responses respectively fail to develop, indicate that the underlying basis of CD4 help is independent of attributes acquired as a response of polarization

This article has been cited by other articles:

• Jing, L., Davies, D. H., Chong, T. M., Chun, S., McClurkan, C. L., Huang, J., Story, B. T., Molina, D. M., Hirst, S., Felgner, P. L., Koelle, D. M. (2008). An Extremely Diverse CD4 Response to Vaccinia Virus in Humans Is Revealed by Proteome-Wide T-Cell Profiling. J. Virol. 82: 7120-7134 [Abstract] [Full Text]