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Infect. Immun. doi:10.1128/IAI.01438-06
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

SiiE is secreted by the Salmonella enterica serovar Typhimurium Pathogenicity Island 4 (SPI-4) -encoded secretion system and contributes to intestinal colonization of cattle

Division of Microbiology, Institute for Animal Health, Compton, Nr Newbury, Berkshire, RG20 7NN, UK

^* To whom correspondence should be addressed. Email: eirwen.morgan{at}bbsrc.ac.uk.

	Abstract

Here we report that Salmonella Pathogenicity Island 4 (SPI-4) of Salmonella Typhimurium encodes a type I secretion system (siiCDF) which secretes a 600 kDa protein (encoded by siiE). SiiE is surface-expressed and its production is regulated by HilA. SiiE and SiiF influence colonization of cattle and invasion of bovine enterocytes.

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