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Infect. Immun. doi:10.1128/IAI.01725-06
Copyright (c) 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Rapid clearance of Lyme disease spirochetes lacking OspC from skin

Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton Montana 59840

^* To whom correspondence should be addressed. Email: ktilly{at}niaid.nih.gov,

	Abstract

We previously demonstrated that Borrelia burgdorferi requires OspC to colonize the mammalian host. To delineate this requirement, we analyzed the clearance of ospC-mutant spirochetes and found that they were eliminated within 48 hours. We conclude that B. burgdorferi uses OspC to resist innate host defenses immediately after transmission.

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