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Infect. Immun. doi:10.1128/IAI.01811-06
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

An In Vitro Model System to Study Adherence and Invasion of Francisella tularensis LVS to Nonphagocytic Cells

Department of Microbiology, Roy J. and Lucille A. Carver School of Medicine, University of Iowa, Iowa City, Iowa 52242

^* To whom correspondence should be addressed. Email: bradley-jones{at}uiowa.edu.

	Abstract

In observing Francisella tularensis interactions with nonphagocytic cell lines in vitro we noted significant adherence, invasion, and intracellular growth of the bacteria within these cells. LVS invasion of nonprofessional phagocytic cells is inhibited by cytochalasin D and nocodazole, suggesting that both the actin and microtubule cytoskeletons are important for invasion.

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