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Infect. Immun. doi:10.1128/IAI.01836-06
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Interferon-gamma suppresses erythropoiesis via interleukin-15

Trudeau Institute, Saranac Lake, NY

^* To whom correspondence should be addressed. Email: mullarky{at}vt.edu.

	Abstract

Impaired erythropoiesis causes anemia during genetic disorders, chronic disease, and infection. Studies of the underlying mechanisms have increasingly focused on IFN. Here, we identify a previously unrecognized role for IL-15 in red blood cell homeostasis and demonstrate that IFN and STAT1-dependent pathways up-regulate expression of IL-15 in vivo. These findings identify new therapeutic targets for anemia.

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