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Infect. Immun. doi:10.1128/IAI.01938-06
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Role of unsaturated fatty acid biosynthesis in virulence of Streptococcus mutans

Department of Microbiology and Immunology, Center for Oral Biology in the Aab Institute for Biomedical Sciences and Eastman Dental Center, University of Rochester School of Medicine and Dentistry, Rochester, New York, 14642

^* To whom correspondence should be addressed. Email: Robert_Quivey{at}urmc.rochester.edu.

	Abstract

An insertionally inactivated fabM strain of S. mutans does not produce unsaturated membrane fatty acids and is acid sensitive (E.M. Fozo and R. G. Quivey, Jr., J. Bacteriol. 186: 4152-4158, 2004). In this study, the strain was shown to be poorly transmissible from host to host. Animals directly infected with the fabM strain exhibited fewer and less severe carious lesions than observed with the wild-type strain.

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