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Infect. Immun. doi:10.1128/IAI.01950-06
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Legionella pneumophila Infection Up-regulates Dendritic Cell TLR 2/4 Expression and Key Maturation Markers

Department of Molecular Medicine, University of South Florida, Tampa, Florida 33612

^* To whom correspondence should be addressed. Email: hfriedma{at}hsc.usf.edu.

	Abstract

Dendritic cells (DCs) have a critical role in linking innate to adaptive immunity and this transition is regulated by the up-regulation of co-stimulatory and MHC molecules as well as Toll-like receptors. These changes in DCs have been observed to occur following microbial infection and in the present study we examined the effect of Legionella pneumophila (Lp) infection on the expression of these DC markers. We showed that bone-marrow-derived DC cultures from BALB/c mice infected with live Lp resulted in up-regulation of Toll-like receptors 2 and 4 and activation of CD40, CD86 and MHC class I/II molecules.